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A : Bar graph showing <t>ICE</t> analysis results of targeting of SMAD4, B2M, KDM6A and TP53 in pKDNFs using Cas9 VLPs. Blue bars: INDEL scores, green bars: KO scores compared to WT control (n≥3; SD shown). B : Bar graph showing ICE analysis results of targeting of IL-10 in developed blastocysts (B1-B6) using multiplexed Cas9 VLPs. Blue bars: INDEL scores, green bars: KO scores compared to WT control. C : <t>Detected</t> <t>INDELs</t> of blastocyst 2 (B2) report that in 98% of the cases, the whole fragment was deleted.
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A : Bar graph showing ICE analysis results of targeting of SMAD4, B2M, KDM6A and TP53 in pKDNFs using Cas9 VLPs. Blue bars: INDEL scores, green bars: KO scores compared to WT control (n≥3; SD shown). B : Bar graph showing ICE analysis results of targeting of IL-10 in developed blastocysts (B1-B6) using multiplexed Cas9 VLPs. Blue bars: INDEL scores, green bars: KO scores compared to WT control. C : Detected INDELs of blastocyst 2 (B2) report that in 98% of the cases, the whole fragment was deleted.

Journal: bioRxiv

Article Title: Virus-Like Particles: The Next Frontier in Livestock Gene Editing

doi: 10.64898/2026.03.30.715406

Figure Lengend Snippet: A : Bar graph showing ICE analysis results of targeting of SMAD4, B2M, KDM6A and TP53 in pKDNFs using Cas9 VLPs. Blue bars: INDEL scores, green bars: KO scores compared to WT control (n≥3; SD shown). B : Bar graph showing ICE analysis results of targeting of IL-10 in developed blastocysts (B1-B6) using multiplexed Cas9 VLPs. Blue bars: INDEL scores, green bars: KO scores compared to WT control. C : Detected INDELs of blastocyst 2 (B2) report that in 98% of the cases, the whole fragment was deleted.

Article Snippet: Sequencing results were analyzed for the percentage of INDELs using the online ICE analysis tool by Synthego ( https://ice.editco.bio ).

Techniques: Control